An agonist of homomeric GABAA receptors
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TACA

Item No. 35217

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-2E-butenoic acid
CAS Number
38090-53-8
Synonyms
  • trans-4-Aminocrotonic Acid
Molecular Formula
C4H7NO2
Formula Weight
101.1
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly solubleWater: slightly soluble
SMILES
OC(/C=C/CN)=O
InChi Code
InChI=1S/C4H7NO2/c5-3-1-2-4(6)7/h1-2H,3,5H2,(H,6,7)/b2-1+
InChi Key
FMKJUUQOYOHLTF-OWOJBTEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $57

    Add

    10 mg

    $107

    Add
    Product Description

    TACA is an agonist of the ρ1 subunit-containing homomeric GABAA receptor, previously known as the GABAC receptor.1,2 It binds to homomeric GABAA receptors (Ki = 0.36 µM) and induces chloride currents in X. laevis oocytes expressing the human receptor (EC50 = 0.53 µM).1 TACA (20 mg/kg) inhibits anxiolytic-like activity induced by the flavonoid quercetin (Item No. 10005169) in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, Y., Covey, D.F., and Weiss, D.S. Correlation of the apparent affinities and efficacies of γ-aminobutyric acidC receptor agonists. Mol. Pharmacol. 58(6), 1375-1380 (2000).

    2. Chebib, M., Vandenberg, R.J., and Johnston, G.A.R. Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br. J. Pharmacol. 122(8), 1551-1560 (1997).

    3. Jung, J.W., and Lee, S. Anxiolytic effects of quercetin: Involvement of GABAergic system. J. Life Sci. 24(3), 290-296 (2014).