A natural non-caloric sweetener and TAS1R2/TAS1R3 agonist
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Rebaudioside M

Item No. 35239

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4α)-13-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl)oxy]-kaur-16-en-18-oic acid, O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl ester
CAS Number
1220616-44-3
Synonyms
  • Reb M
  • Rebaudioside X
Molecular Formula
C56H90O33
Formula Weight
1291.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
C[C@]1(CCC2)[C@@](CC3)([H])[C@@](CC4=C)(CC[C@]1([H])[C@]2(C)C(O[C@H](O[C@@H]5CO)[C@@H]([C@H]([C@@H]5O)O[C@]([C@@H]([C@H]6O)O)([H])O[C@@H]([C@H]6O)CO)O[C@]([C@@H]([C@H]7O)O)([H])O[C@@H]([C@H]7O)CO)=O)C[C@]43O[C@@](O[C@@H]8CO)([H])[C@@H]([C@H]([C@@H]8O)O[C@]([C@@H]([C@H]9O)O)([H])O[C@@H]([C@H]9O)CO)O[C@]([C@@H]([C@H]%10O)O)([H])O[C@@H]([C@H]%10O)CO
InChi Code
InChI=1S/C56H90O33/c1-19-11-55-9-5-26-53(2,7-4-8-54(26,3)52(77)88-50-44(86-48-40(75)36(71)30(65)22(14-59)80-48)42(32(67)24(16-61)82-50)84-46-38(73)34(69)28(63)20(12-57)78-46)27(55)6-10-56(19,18-55)89-51-45(87-49-41(76)37(72)31(66)23(15-60)81-49)43(33(68)25(17-62)83-51)85-47-39(74)35(70)29(64)21(13-58)79-47/h20-51,57-76H,1,4-18H2,2-3H3/t20-,21-,22-,23-,24-,25-,26+,27+,28-,29-,30-,31-,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44-,45-,46+,47+,48+,49+,50+,51+,53-,54-,55-,56+/m1/s1
InChi Key
GSGVXNMGMKBGQU-PHESRWQRSA-N
Origin
Plant/Stevia rebaudiana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $118

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    10 mg

    $203

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    25 mg

    $426

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    Product Description

    Rebaudioside M is a natural non-caloric sweetener and an agonist of the class 1 sweet taste receptor (TAS1R) heterodimer formed by TAS1R2 and TAS1R3.1 It is one of the minor steviol glycosides isolated from S. rebaudiana leaves.2 Rebaudioside M increases intracellular calcium levels in HEK293 cells expressing human TAS1R2 and TAS1R3 (EC50 = 29.54 µM) and has a relative sweetness potency 200-350 times that of sucrose.1,2 Rebaudioside M is metabolized by gut microbiota to steviol, a compound whose safety is widely studied.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Choi, Y., Manthey, J.A., Park, T.H., et al. Correlation between in vitro binding activity of sweeteners to cloned human sweet taste receptor and sensory evaluation. Food Sci. Biotechnol. 30(5), 675-682 (2021).

    2. Prakash, I., Markosyan, A., and Bunders, C. Development of next generation Stevia sweetener: Rebaudioside M. Foods 3(1), 162-175 (2014).

    3. Purkayastha, S., Markosyan, A., Prakash, I., et al. Steviol glycosides in purified stevia leaf extract sharing the same metabolic fate. Regul. Toxicol. Pharmacol. 77, 125-133 (2016).

    4. Roberts, A., and Renwick, A.G. Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats. Food Chem. Toxicol. 46(Suppl 7), S31-S39 (2008).