A derivative of biopterin
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Product Categories

Product Type

Biochemicals

Research Area

Cancer

Rhamnopterin

Item No. 35254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-6-(1,2,3-trihydroxybutyl)-4(3H)-pteridinone
CAS Number
13392-24-0
Molecular Formula
C10H13N5O4
Formula Weight
267.2
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C1N=C(N)N=C2NC=C(C(C(C(C)O)O)O)N=C12
InChi Code
InChI=1S/C10H13N5O4/c1-3(16)6(17)7(18)4-2-12-8-5(13-4)9(19)15-10(11)14-8/h2-3,6-7,16-18H,1H3,(H3,11,12,14,15,19)
InChi Key
QSVZLFABRHDXRR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $218

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    10 mg

    $339

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    25 mg

    $543

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    Product Description

    Rhamnopterin is a derivative of L-biopterin (Item No. 10007662), the oxidized form of tetrahydro-L-biopterin (BH4), and D-biopterin (Item No. 34201).1 Dietary administration of rhamnopterin (0.5%) concurrently with the carcinogen 4-dimethylaminoazobenzene reduces the incidence of 4-dimethylaminoazobenzene-induced liver tumors in rats. Rhamnopterin has been used as an internal standard for the quantification of biopterin and neopterin in rat plasma by LC-MS.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sasaki, H., Nagase, S., Fujimaki, C., et al. Effect of polyhydroxy-alkylpterins on the development of liver cancers in the rat fed with 4-dimethylaminoazobenzene. Gan. 55, 297-304 (1964).

    2. Pickert, G., Lim, H.-Y., Weigert, A., et al. Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages. Int. J. Cancer 132(3), 591-604 (2013).