An MCH-derived peptide and MCH receptor agonist
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[Ala17]-MCH (trifluoroacetate salt)

Item No. 35262

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17-L-alanine-melanin-concentrating hormone (human), trifluoroacetate salt
Synonyms
  • [Ala17]-Melanin-Concentrating Hormone
Molecular Formula
C97H155N29O26S4 • XCF3COOH
Formula Weight
2271.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C[C@H](N[H])C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@H](N1)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)C)=O)C(N[C@@H](CCSC)C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C1=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC4=CC=CC=C4)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C97H155N29O26S4.C2HF3O2/c1-48(2)39-63-79(136)109-45-72(129)111-57(21-15-33-106-95(100)101)83(140)124-75(50(5)6)92(149)121-66(42-54-25-27-55(127)28-26-54)86(143)116-62(23-17-35-108-97(104)105)93(150)126-36-18-24-70(126)91(148)123-68(89(146)110-52(9)77(134)112-59(29-30-71(99)128)84(141)125-76(51(7)8)94(151)152)46-155-156-47-69(90(147)115-61(32-38-154-11)81(138)118-63)122-80(137)58(22-16-34-107-96(102)103)113-85(142)64(40-49(3)4)119-82(139)60(31-37-153-10)114-88(145)67(44-74(132)133)120-87(144)65(41-53-19-13-12-14-20-53)117-78(135)56(98)43-73(130)131;3-2(4,5)1(6)7/h12-14,19-20,25-28,48-52,56-70,75-76,127H,15-18,21-24,29-47,98H2,1-11H3,(H2,99,128)(H,109,136)(H,110,146)(H,111,129)(H,112,134)(H,113,142)(H,114,145)(H,115,147)(H,116,143)(H,117,135)(H,118,138)(H,119,139)(H,120,144)(H,121,149)(H,122,137)(H,123,148)(H,124,140)(H,125,141)(H,130,131)(H,132,133)(H,151,152)(H4,100,101,106)(H4,102,103,107)(H4,104,105,108);(H,6,7)/t52-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,75-,76-;/m0./s1
InChi Key
QUUMBKKSOOYPSH-QESJKDSYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $125

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    10 mg

    $217

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    25 mg

    $465

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    Product Description

    [Ala17]-MCH is a synthetic peptide derived from the hypothalamic neuropeptide hormone melanin-concentrating hormone (MCH) and an MCH receptor agonist.1 It binds to MCH1 and MCH2 receptors in CHO cells expressing the human receptors (IC50s = 0.15 and 3.5 nM, respectively) and induces calcium mobilization in HEK293 cells expressing the human receptors (EC50s = 17 and 54 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bednarek, M.A., Feighner, S.D., Hreniuk, D.L., et al. Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. Biochemistry 40(31), 9379-9386 (2001).