A neuropeptide and MRGPRX1 agonist
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BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt)

Item No. 35263

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valylglycyl-L-arginyl-L-prolyl-L-α-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-glycine, trifluoroacetate salt
Synonyms
  • BAM 8-22
  • Bovine Adrenal Medulla 8-22
Molecular Formula
C91H127N25O23S • XCF3COOH
Formula Weight
1971.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1mg/ml
SMILES
OC(CNC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC3=CNC4=CC=CC=C34)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H]5N(CCC5)C([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C91H127N25O23S/c1-48(2)76(94)88(138)103-46-72(120)105-64(19-11-36-100-91(97)98)89(139)116-37-12-20-70(116)87(137)110-62(30-32-73(121)122)81(131)113-68(42-52-45-102-58-16-7-5-14-56(52)58)85(135)114-67(41-51-44-101-57-15-6-4-13-55(51)57)84(134)109-63(33-38-140-3)82(132)115-69(43-74(123)124)86(136)112-66(40-50-23-27-54(118)28-24-50)83(133)108-61(29-31-71(93)119)80(130)106-59(17-8-9-34-92)78(128)107-60(18-10-35-99-90(95)96)79(129)111-65(77(127)104-47-75(125)126)39-49-21-25-53(117)26-22-49/h4-7,13-16,21-28,44-45,48,59-70,76,101-102,117-118H,8-12,17-20,29-43,46-47,92,94H2,1-3H3,(H2,93,119)(H,103,138)(H,104,127)(H,105,120)(H,106,130)(H,107,128)(H,108,133)(H,109,134)(H,110,137)(H,111,129)(H,112,136)(H,113,131)(H,114,135)(H,115,132)(H,121,122)(H,123,124)(H,125,126)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,76-/m0/s1
InChi Key
GOEYECACIBFJGZ-NPAGUKBMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $329

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    5 mg

    $1,070

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    Product Description

    BAM-22P (8-22) is an endogenous neuropeptide derived from proenkephalin A and an agonist of MAS-related G protein-coupled receptor family member X1 (MRGPRX1), previously known as sensory neuron-specific G protein-coupled receptor 4 (SNSR4).1 It is involved in prurition and nociception. BAM-22P (8-22) induces calcium mobilization in HEK293S cells expressing human MRGPRX1 or SNSR3 (EC50s = 14 and 28 nM, respectively) and inhibits voltage-induced calcium currents in isolated rat neurons expressing human MRGPRX1 (EC50 = 0.6 µM).2 Intrathecal administration of BAM-22P (8-22) (30 nmol/animal) decreases the tail-flick latency in rats stimulated with the Gαi inhibitor pertussin toxin and increases the tail-flick latency in rats stimulated with the phospholipase C (PLC) inhibitor U-73122, indicating changes in pain sensitivity.3 BAM-22P (8-22) (100 µg/animal) increases scratching behavior in wild-type mice and enhances bile-duct ligation-induced scratching behavior in a mouse model of cholestasis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lembo, P.M.C., Grazzini, E., Groblewski, T., et al. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat. Neurosci. 5(3), 201-209 (2002).

    2. Chen, H., and Ikeda, S.R. Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J. Neurosci. 24(21), 5044-5053 (2004).

    3. Chen, T., Wang, D., and Hong, Y. Dual modulation effects of Mas-related gene (Mrg) receptors on pain sensitivity in rats. Neurosci. Lett. 514(1), 82-85 (2012).

    4. Sanjel, B., Maeng, H.-J., and Shim, W.-S. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci. Rep. 9(1), 10888 (2019).