A metabolite of cholic acid
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7-keto Deoxycholic Acid

Item No. 35264

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-3α,12α-dihydroxy-7-oxo-cholan-24-oic acid
CAS Number
911-40-0
Synonyms
  • 5β-Cholanic Acid-3α,12α-diol-7-one
  • 7-keto DCA
Molecular Formula
C24H38O5
Formula Weight
406.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 2 mg/mlEthanol: 15 mg/ml
SMILES
O[C@@H]1CC[C@@]2(C)[C@@](CC([C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(O)=O)=O)([H])C1
InChi Code
InChI=1S/C24H38O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-18,20,22,25,27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,20+,22+,23+,24-/m1/s1
InChi Key
RHCPKKNRWFXMAT-RRWYKFPJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    Product Description

    7-keto Deoxycholic acid is a metabolite of the primary bile acid cholic acid (Item No. 20250).1,2 Fecal levels of 7-keto deoxycholic acid are elevated in rats fed a diet supplemented with cholic acid compared with rats fed a control diet or a diet supplemented with cholesterol (Item No. 9003100).1 Hepatic levels of 7-keto deoxycholic acid are elevated in a mouse model of ethanol-induced alcoholic liver disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sakai, K., Makino, T., Kawai, Y., et al. Intestinal microflora and bile acids. Effect of bile acids on the distribution of microflora and bile acid in the digestive tract of the rat. Microbiol. Immunol. 24(3), 187-196 (1980).

    2. Hirano, S., Masuda, N., Oda, H., et al. Transformation of bile acids by Clostridium perfringens. Appl. Environ. Microbiol. 42(3), 394-399 (1981).

    3. Charkoftaki, G., Tan, W.Y., Berrios-Carcamo, P., et al. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice. Chem. Biol. Interact. 360, 109931 (2022).