An EAAT inhibitor
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DL-threo-β-Hydroxyaspartic Acid

Item No. 35274

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-3R-hydroxy-D-aspartic acid
CAS Number
4294-45-5
Synonyms
  • DL-THA
  • DL-threo-3-Hydroxyaspartic Acid
Molecular Formula
C4H7NO5
Formula Weight
149.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleChloroform: Slightly solubleDMF: Slightly solubleDMSO: Slightly solubleEthanol: Slightly solublePBS (pH 7.2): Slightly solubleWater: Slightly soluble
SMILES
OC([C@@H](O)[C@H](N)C(O)=O)=O
InChi Code
InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
InChi Key
YYLQUHNPNCGKJQ-LWMBPPNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $98

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    50 mg

    $178

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    100 mg

    $294

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    Product Description

    DL-threo-β-Hydroxyaspartic acid is an inhibitor of excitatory amino acid transporters (EAATs).1,2 It inhibits glutamate uptake in COS-1 cells expressing human EAAT1 or EAAT2 (IC50s = 96 and 31 µM, respectively) as well as inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 0.6 µM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 2.5 µM) voltage-clamped at -60 mV. Intrathecal administration of DL-threo-β-hydroxyaspartic acid (7.5 and 15 µg/animal) reduces the number of flinches and shakes in the second phase of the formalin test in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimamoto, K., Lebrun, B., Yasuda-Kamatani, Y., et al. ᴅʟ-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol. Pharmacol. 53(2), 195-201 (1998).

    2. Shigeri, Y., Shimamoto, K., Yasuda-Kamatani, Y., et al. Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J. Neurochem. 79(2), 297-302 (2001).

    3. Yaster, M., Guan, X., Petralia, R.S., et al. Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund’s adjuvant. Anesthesiology 114(2), 412-423 (2011).