Rimiducid

Rimiducid is a chemical inducer of dimerization (CID) for fusion proteins of the FK506 binding protein (FKBP) mutant FKBPF36V.¹ It selectively binds to FKBP^F36V over wild-type FKBP (IC₅₀s = 0.005 and >10 µM, respectively). Rimiducid induces apoptosis in HT-1080 fibrosarcoma cells expressing a FKBP^F36V fusion protein with the intracellular domain of Fas, also known as CD95, that contains a myristoylation sequence (EC₅₀ = ~0.1 nM). It also induces apoptosis in primary human T lymphocytes expressing a FKBP^F36V-Fas fusion protein (IC₅₀ = ~0.2 nM).² Rimiducid decreases serum human growth hormone (hGH) levels in mice injected with HT-1080 cells expressing FKBP^F36V-Fas that constitutively secrete hGH, indicating conditional cell ablation (ED₅₀ = 0.4 mg/kg).¹

WARNING This product is not for human or veterinary use.

1. Clackson, T., Yang, W., Rozamus, L.W., et al. Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity. Proc. Natl. Acad. Sci. USA 95(18), 10437-10442 (1998).

2. Thomis, D.C., Marktel, S., Bonini, C., et al. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood 97(5), 1249-1257 (2022).