A terpene trilactone with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ginkgolide K

Item No. 35304

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,3S,3aS,4R,6aR,7aS,10aR,11R,11aR)-3-(1,1-dimethylethyl)-2,3,10a,11-tetrahydro-4,11-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
CAS Number
153355-70-5
Molecular Formula
C20H22O9
Formula Weight
406.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
O[C@@H]([C@]1([H])OC2=O)[C@]3([C@@](O4)([H])C[C@H]5C(C)(C)C)[C@@]5([C@H]6O)[C@](OC6=O)([H])O[C@@]3(C4=O)C1=C2C
InChi Code
InChI=1S/C20H22O9/c1-6-9-10(27-13(6)23)11(21)19-8-5-7(17(2,3)4)18(19)12(22)14(24)28-16(18)29-20(9,19)15(25)26-8/h7-8,10-12,16,21-22H,5H2,1-4H3/t7-,8+,10+,11-,12-,16-,18-,19+,20+/m0/s1
InChi Key
MGXAKXRVQRODDX-LRSNRTHXSA-N
Origin
Plant/Ginkgo biloba L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $82

    Add

    5 mg

    $262

    Add

    10 mg

    $443

    Add

    25 mg

    $905

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Ginkgolide K is a terpene trilactone that has been found in G. biloba and has diverse biological activities.1,2,3 It reduces corpus callosum demyelination, increases the distance traveled in the elevated plus maze, and reduces immobility time in the forced swim test in mice in a model of cuprizone-induced demyelination when administered at a dose of 20 mg/kg per day.2 Ginkgolide K (4 and 8 mg/kg) reduces infarct volume, improves neurological deficits, reverses decreases in superoxide dismutase (SOD) activity, and reverses increases in the levels of malondialdehyde (MDA) and nitric oxide (NO) in cerebral ischemic sections and serum in a rat model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Beek, T.A. Ginkgolides and bilobalide: Their physical, chromatographic and spectroscopic properties. Bioorg. Med. Chem. 13(17), 5001-5012 (2005).

    2. Li, Q.-Y., Miao, Q., Sui, R.-X., et al. Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis. Int. Immunopharmacol. 75, 105819 (2019).

    3. Ma, S., Yin, H., Chen, L., et al. Neuroprotective effect of ginkgolide K against acute ischemic stroke on middle cerebral ischemia occlusion in rats. J. Nat. Med. 66(1), 25-31 (2012).