For immunochemical detection of NKX3.1
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NKX3.1 (N-Term) Rabbit Monoclonal Antibody (Clone RM430)

Item No. 35320

Product Insert (PDF)
Technical Information
Synonyms
  • Homeobox Protein Nkx-3.1
  • NK3 Homeobox 1
  • NKX3A
Immunogen
A peptide corresponding to the N-terminus of human protein Nkx3.1
Clone Designation
RM430
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC
Cross Reactivity
(-) NKX3.1
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    NKX3.1 is a homeoprotein transcription factor expressed solely in prostate epithelial cells that is essential to normal prostate development.1 It functions as a tumor suppressor, regulating gene expression and cell proliferation in a non-cell autonomous manner.1 NKX3.1 forms complexes with the androgen receptor to mediate DNA repair generated during transcriptional activation and is activated in response to DNA damage to accelerate damage repair via activation of ataxia-telangiectasia mutated kinase (ATM).2,3 NKX3.1 can also be imported to the mitochondria by the chaperone protein HSPA9 where it induces expression of mitochondrial-encoded electron transport chain genes to restore oxidative phosphorylation under oxidative stress conditions.4 Loss of NKX3.1 expression is associated with hormone-refractoriness and advanced tumor stage in patients with prostate cancer.5 It has been used as a biomarker for prostate cancer and to determine the origin of metastatic tumors.6 Cayman's NKX3.1 Rabbit Monoclonal Antibody (Clone RM430) can be used for immunohistochemistry (IHC).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, J., Qin, L., Tien, J.C.-Y., et al. Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner. The Journal of Biological Chemisty 287(21), 17248-17256 (2012).

    2. Zhang, H., Zheng, T., Chua, C.W., et al. Nkx3.1 controls the DNA repair response in the mouse prostate. Prostate 76(4), 402-408 (2016).

    3. Bowen, C., and Gelmann, E.P. NKX3.1 activates cellular response to DNA damage. Cancer Res. 70(8), 3089-3097 (2010).

    4. Papachristodoulou, A., Rodriguez-Calero, A., Panja, S., et al. NKX3.1 localization to mitochondria suppresses prostate cancer initiation. Cancer Discov. 11(9), 2316-2333 (2021).

    5. Bowen, C., Bubendorf, L., Voeller, H.J., et al. Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression. Cancer Res. 60(21), 6111-6115 (2000).

    6. Shen, J.Z., Memon, A.A., Hackney, J.R., et al. NKX3.1 identifies prostatic origin of dural metastasis in the setting of negative prostate-specific antigen stain. Neurohospitalist 10(4), 314-317 (2020).