A copper-containing bis(thiosemicarbazone) complex
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Cu-ATSP

Item No. 35322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-4-2)-[[2, 2′-(1,2-dimethyl-1,2-ethanediylidene)bis[N-phenylhydrazinecarbothioamidato-κN2,κS]](2-)]-copper
CAS Number
68341-12-8
Synonyms
  • copper-ATSP
  • CuII(atsp)
Molecular Formula
C18H18CuN6S2
Formula Weight
446.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/ml
λmax
247, 315, 395, 494 nm
SMILES
CC1=[N-]2N=C(NC3=CC=CC=C3)S[Cu+2]42SC(NC5=CC=CC=C5)=N[N-]4=C1C
InChi Code
InChI=1S/C18H20N6S2.Cu/c1-13(21-23-17(25)19-15-9-5-3-6-10-15)14(2)22-24-18(26)20-16-11-7-4-8-12-16;/h3-12H,1-2H3,(H2,19,23,25)(H2,20,24,26);/q;+2/p-2/b21-13+,22-14+;
InChi Key
YYPBOUNODSJBJR-JKBLJYNNSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $105

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    10 mg

    $192

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    25 mg

    $433

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    Product Description

    Cu-ATSP is a copper-containing bis(thiosemicarbazone) complex with ferroptosis inhibitory activity.1 It traps peroxyl radicals in a cell-free assay when used at a concentration of 6 µM. Cu-ATSP inhibits ferroptosis induced by (1S,3R)-RSL3 (Item No. 19288) in Pfa1 mouse embryonic fibroblasts (MEFs) and HT22 mouse hippocampal cells (EC50s = 8.5 and 16 nM, respectively). It increases intracellular copper levels but, unlike the bis(thiosemicarbazone) complexes Cu-CQ2 and CuNC2, does not reduce amyloid-β (1-40) (Aβ40) levels in CHO cells overexpressing amyloid precursor protein (APP).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zilka, O., Poon, J.-F., and Pratt, D.A. Radical-trapping antioxidant activity of copper and nickel bis(thiosemicarbazone) complexes underlies their potency as inhibitors of ferroptotic cell death. J. Am. Chem. Soc. 143(45), 19043-19057 (2021).

    2. Donnelly, P.S., Caragounis, A., Du, T., et al. Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-β peptide. The Journal of Biological Chemisty 283(8), 4568-4577 (2008).