A glutathione analog and biomarker of hepatic glutathione depletion
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Ophthalmic Acid (trifluoroacetate salt)

Item No. 35343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-γ-glutamyl-(2S)-2-aminobutanoyl-glycine, monohydrochloride
CAS Number
495-27-2
Molecular Formula
C11H19N3O6 • XCF3COOH
Formula Weight
289.3
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 12 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
OC(CNC([C@H](CC)NC(CC[C@H](N)C(O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C11H19N3O6.C2HF3O2/c1-2-7(10(18)13-5-9(16)17)14-8(15)4-3-6(12)11(19)20;3-2(4,5)1(6)7/h6-7H,2-5,12H2,1H3,(H,13,18)(H,14,15)(H,16,17)(H,19,20);(H,6,7)/t6-,7-;/m0./s1
InChi Key
FIQINFGRSGAOAY-LEUCUCNGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    25 mg

    $218

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    50 mg

    $267

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    Product Description

    Ophthalmic acid is a glutathione (GSH) analog and biomarker of hepatic glutathione depletion.1 It is formed via the GSH synthesis pathway, substituting 2-aminobutyrate for cysteine. Plasma and hepatic levels of ophthalmic acid are increased in fasted mice and in a mouse model of acetaminophen-induced hepatotoxicity.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kobayashi, S., Lee, J., Takao, T., et al. Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice. Biochem. Biophys. Res. Commun. 491(3), 649-655 (2017).

    2. Soga, T., Baran, R., Suematsu, M., et al. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. The Journal of Biological Chemisty 281(24), 16768-16776 (2006).