An ASBT inhibitor
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Odevixibat

Item No. 35344

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-[[(2R)-2-[[2-[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-butanoic acid
CAS Number
501692-44-0
Synonyms
  • A4250
Molecular Formula
C37H48N4O8S2
Formula Weight
740.9
Purity
≥90%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
223, 281 nm
SMILES
O=S1(C2=CC(OCC(N[C@H](C3=CC=C(C=C3)O)C(N[C@@H](CC)C(O)=O)=O)=O)=C(SC)C=C2N(C4=CC=CC=C4)CC(CCCC)(N1)CCCC)=O
InChi Code
InChI=1S/C37H48N4O8S2/c1-5-8-19-37(20-9-6-2)24-41(26-13-11-10-12-14-26)29-21-31(50-4)30(22-32(29)51(47,48)40-37)49-23-33(43)39-34(25-15-17-27(42)18-16-25)35(44)38-28(7-3)36(45)46/h10-18,21-22,28,34,40,42H,5-9,19-20,23-24H2,1-4H3,(H,38,44)(H,39,43)(H,45,46)/t28-,34+/m0/s1
InChi Key
XULSCZPZVQIMFM-IPZQJPLYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $165

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    10 mg

    $295

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    25 mg

    $520

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    Product Description

    Odevixibat is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT; IC50 = 0.16 nM).1 It inhibits intestinal reabsorption of [75Se]homotaurocholic acid (75SeHCAT) by 74% in ApoE-/- mice when administered at a dose of 0.156 µmol/kg. Formulations containing odevixibat have been used in the treatment of pruritis in patients with progressive familial intrahepatic cholestasis, an inborn error of metabolism characterized by mutations in various genes involved in bile production and transport, including ATP8B1 and ABCB11.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gillberg, P.-G., Graffner, H., and Ingemar, S. IBAT inhibitors for the treatment of liver disease. (2017).