A corticosteroid
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Hydrocortisone Aceponate

Item No. 35359

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β)-21-(acetyloxy)-11-hydroxy-17-(1-oxopropoxy)-pregn-4-ene-3,20-dione
CAS Number
74050-20-7
Synonyms
  • Hydrocortisone 17-Propionate 21-Acetate
Molecular Formula
C26H36O7
Formula Weight
460.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): insol
λmax
242 nm
SMILES
C[C@@]12[C@](C(COC(C)=O)=O)(OC(CC)=O)CC[C@@]1([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])[C@H](C2)O
InChi Code
InChI=1S/C26H36O7/c1-5-22(31)33-26(21(30)14-32-15(2)27)11-9-19-18-7-6-16-12-17(28)8-10-24(16,3)23(18)20(29)13-25(19,26)4/h12,18-20,23,29H,5-11,13-14H2,1-4H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1
InChi Key
MFBMYAOAMQLLPK-FZNHGJLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    Hydrocortisone aceponate is a corticosteroid.1,2 Topical application of hydrocortisone aceponate (0.0584%) reduces lesion size and pruritis in cats with allergic dermatitis.1 It also induces remission and increases time to relapse in dogs with spontaneous atopic dermatitis.2 Formulations containing hydrocortisone aceponate have been used in the treatment of veterinary dermatoses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmidt, V., Buckley, L.M., McEwan, N.A., et al. Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: An open label pilot study. Vet. Dermatol. 23(1), 11-16 (2012).

    2. Lourenço, A.M., Schmidt, V., Braz, B.S., et al. Efficacy of proactive long-term maintenance therapy of canine atopic dermatitis with 0.0584% hydrocortisone aceponate spray: A double-blind placebo controlled pilot study. Vet. Dermatol. 27(2), 88e25-92e25 (2016).