A dihydroxy fatty acid synthesized by 15-LO from 15(S)-HETE
Related Products
Parent Compound(s)
3472015(S)-HETE
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

8(S),15(S)-DiHETE

Item No. 35370

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid
CAS Number
80234-65-7
Molecular Formula
C20H32O4
Formula Weight
336.5
Purity
≥95%
Formulation (Request formulation change)
A 250 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 1 mg/ml
λmax
268 nm
SMILES
CCCCC[C@H](O)/C=C/C=C\C=C\[C@@H](O)C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C20H32O4/c1-2-3-8-13-18(21)14-9-4-5-10-15-19(22)16-11-6-7-12-17-20(23)24/h4-6,9-11,14-15,18-19,21-22H,2-3,7-8,12-13,16-17H2,1H3,(H,23,24)/b5-4-,11-6-,14-9+,15-10+/t18-,19+/m0/s1
InChi Key
NNPWRKSGORGTIM-HCCKYKKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 µg

    $105

    Add

    50 µg

    $197

    Add

    100 µg

    $371

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO.1 It causes eosinophil chemotaxis with an ED50 value of 1.5 µM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes the hyperalgesic activity of 8(R),15(S)-DiHETE and LTB4 in the rat hind paw pain model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morita, E., Schröder, J.M., and Christophers, E. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid. J. Immunol. 144, 1893-1900 (1990).

    2. Levine, J.D., Lam, D., Taiwo, Y.O., et al. Hyperalgesic properties of 15-lipoxygenase products of arachidonic acid. Proc. Natl. Acad. Sci. USA 83, 5331-5334 (1986).

    Product Citations

    Brouwers, H., Jónasdóttir, H.S., Kuipers, M.E., et al. Anti-inflammatory and proresolving effects of the omega-6 polyunsaturated fatty acid adrenic acid. J. Immunol. 205(10), 2840-2849 (2020).