A GPX4 inhibitor
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GPX4 Inhibitor 26a

Item No. 35408

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(2-chloroacetyl)[4-(5-oxazolyl)phenyl]amino]-N-(2-phenylethyl)-benzo[b]thiophene-3-acetamide
CAS Number
2761004-85-5
Synonyms
  • Glutathione Peroxidase 4 Inhibitor 26a
  • GPX4-IN-3
  • PHGPx Inhibitor 26a
  • Phospholipid Hydroperoxide Glutathione Peroxidase Inhibitor 26a
Molecular Formula
C29H24ClN3O3S
Formula Weight
530.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
λmax
269 nm
SMILES
ClCC(N(C(C1=CSC2=CC=CC=C21)C(NCCC3=CC=CC=C3)=O)C4=CC=C(C5=CN=CO5)C=C4)=O
InChi Code
InChI=1S/C29H24ClN3O3S/c30-16-27(34)33(22-12-10-21(11-13-22)25-17-31-19-36-25)28(24-18-37-26-9-5-4-8-23(24)26)29(35)32-15-14-20-6-2-1-3-7-20/h1-13,17-19,28H,14-16H2,(H,32,35)
InChi Key
ZLCPSXKEQBUXRJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $62

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    5 mg

    $258

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    10 mg

    $486

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    Cayman Chemical
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    Product Description

    GPX4 inhibitor 26a is an inhibitor of glutathione peroxidase 4 (GPX4).1 It inhibits GPX4 activity by 71.7% at 1 µM. GPX4 inhibitor 26a is cytotoxic to 4T1 and MCF-7 breast cancer cells and HT-1080 fibrosarcoma cells (IC50s = 0.78, 6.9, and 0.15 µM, respectively). It decreases intracellular glutathione (GSH) levels and induces lipid peroxidation and ferroptosis in 4T1 cells when used at a concentration of 5 µM. GPX4 inhibitor 26a (15 and 30 mg/kg) reduces tumor growth in a 4T1 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, C., Xiao, Z., Wang, J., et al. Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer. J. Med. Chem. 64(18), 13312-13326 (2021).