An internal standard for the quantification of salicylic acid
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Salicylic Acid-d4

Item No. 35418

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-hydroxy-benzoic-2,3,4,5-d4 acid
CAS Number
78646-17-0
Synonyms
  • 2-Hydroxybenzoic Acid-d4
Molecular Formula
C7H2D4O3
Formula Weight
142.1
Purity
≥99% deuterated forms (d1-d4)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
OC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])O)=O
InChi Code
InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)/i1D,2D,3D,4D
InChi Key
YGSDEFSMJLZEOE-RHQRLBAQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $44

    Add

    10 mg

    $80

    Add

    25 mg

    $174

    Add

    50 mg

    $260

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Salicylic acid-d4 is intended for use as an internal standard for the quantification of salicylic acid by GC- or LC-MS. Salicylic acid is an active metabolite of the COX inhibitor aspirin (Item No. 70260) and a plant hormone that has been found in Cucumis sativus.1,2 It protects Cucumis sativus leaves from infection by S. fuliginea or E. cichoracearum when used at a concentration of 10 mM, as well as inhibits A. thaliana root growth at 0.3 mM.2,3 Salicylic acid (1 and 4 mM) reduces IFN-γ- and TNF-α-induced increases in NOS2 expression in primary rat cardiac fibroblasts.4 It decreases urine prostaglandin E2 (PGE2; Item No. 14010) levels in dogs when administered at a dose of 40 mg/kg.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Klessig, D.F. Newly identified targets of aspirin and its primary metabolite, salicylic acid. DNA Cell Biol. 35(4), 163-166 (2016).

    2. Feussner, I., Fritz, I.G., Hause, B., et al. Induction of a new lipoxygenase form in cucumber leaves by salicylic acid or 2,6-dichloroisonicotinic acid. Botanica Acta 110, 101-108 (1997).

    3. Kim, T.-H., Kunz, H.-H., Bhattacharjee, S., et al. Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis. Plant Cell 24(12), 5177-5192 (2012).

    4. Farivar, R.S., and Brecher, P. Salicylate is a transcriptional inhibitor of the inducible nitric oxide synthase in cultured cardiac fibroblasts. The Journal of Biological Chemisty 271, 31585-31592 (1996).

    5. Zambraski, E.J., Atkinson, D.C., and Diamond, J. Effects of salicylate vs. aspirin on renal prostaglandins and function in normal and sodium-depleted dogs. J. Pharmacol. Exp. Ther. 247(1), 96-103 (1988).