An antiviral agent
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AT-130

Item No. 35453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1E)-2-bromo-2-(2-methoxyphenyl)-1-(1-piperidinylcarbonyl)ethenyl]-4-nitro-benzamide
CAS Number
211364-06-6
Molecular Formula
C22H22BrN3O5
Formula Weight
488.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/ml w/ sonicationEthanol: soluble
SMILES
Br/C(C1=C(C=CC=C1)OC)=C(NC(C2=CC=C(C=C2)[N+]([O-])=O)=O)\C(N3CCCCC3)=O
InChi Code
InChI=1S/C22H22BrN3O5/c1-31-18-8-4-3-7-17(18)19(23)20(22(28)25-13-5-2-6-14-25)24-21(27)15-9-11-16(12-10-15)26(29)30/h3-4,7-12H,2,5-6,13-14H2,1H3,(H,24,27)/b20-19+
InChi Key
OQIUTYABZMBBME-FMQUCBEESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    AT-130 is an antiviral agent.1,2 It is a non-nucleoside inhibitor of hepatitis B virus (HBV) replication in wild-type and rtL180M, rtM204I, and rtL180M + rtL204V lamivudine-resistant strains of HBV (IC50s = 2.4, 1.6, 5.1, and 1.3 µM, respectively).2 AT-130 inhibits viral DNA synthesis in HBV-infected HepAD38 cells (EC50 = 0.13 µM) and reduces the amount of encapsidated RNA in HBV-infected HepG2 cells.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perni, R.B., Conway, S.C., Ladner, S.K., et al. Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication. Bioorg. Med. Chem. Lett. 10(23), 2687-2690 (2000).

    2. Delaney, W.E., IV, Edwards, R., Colledge, D., et al. Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro. Antimicrob. Agents Chemother. 46(9), 3057-3060 (2002).

    3. Feld, J.J., Colledge, D., Sozzi, V., et al. The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packaging. Antiviral Res. 76(2), 168-177 (2007).