A peptide agonist of NK1 receptors
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Hemokinin 1 (human) (trifluoroacetate salt)

Item No. 35458

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-threonylglycyl-L-lysyl-L-alanyl-L-seryl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide, trifluoroacetate salt
Synonyms
  • HK-1
  • Tachykinin-4 (57-67)
  • Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2
Molecular Formula
C54H84N14O14S • XCF3COOH
Formula Weight
1185.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
TGKASQFFGLM-NH2
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@@H](N)[C@H](O)C)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C54H84N14O14S.C2HF3O2/c1-30(2)24-38(51(79)64-35(46(58)74)21-23-83-5)63-44(73)27-59-48(76)39(25-33-14-8-6-9-15-33)66-52(80)40(26-34-16-10-7-11-17-34)67-50(78)37(19-20-42(56)71)65-53(81)41(29-69)68-47(75)31(3)61-49(77)36(18-12-13-22-55)62-43(72)28-60-54(82)45(57)32(4)70;3-2(4,5)1(6)7/h6-11,14-17,30-32,35-41,45,69-70H,12-13,18-29,55,57H2,1-5H3,(H2,56,71)(H2,58,74)(H,59,76)(H,60,82)(H,61,77)(H,62,72)(H,63,73)(H,64,79)(H,65,81)(H,66,80)(H,67,78)(H,68,75);(H,6,7)/t31-,32+,35-,36-,37-,38-,39-,40-,41-,45-;/m0./s1
InChi Key
QLLAEPTWWMMZIN-DWEDQCKHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Hemokinin 1 is a tachykinin peptide neurokinin-1 (NK1) receptor agonist.1,2,3,4,5 It induces migration of A375 and B16/F10 melanoma cells when used at a concentration of 1 µM, an effect that can be reversed by the NK1 receptor antagonist L-732,138 (Item No. 30894).1 Hemokinin 1 (0.001-0.1 µM) promotes the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs).2 It induces the production of prostaglandin E2 (PGE2; Item No. 14010) in human colon mucosal and muscle explants.3 Intracerebroventricular administration of hemokinin 1 increases the latency to withdrawal in the tail-flick test in mice in a dose-dependent manner.4 It decreases mean arterial pressure (MAP) and heart rate in anesthetized rats when administered at doses ranging from 1 to 30 nmol/kg.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, Y., Li, X., Li, J., et al. Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors. Peptides 83, 8-15 (2016).

    2. Song, H., Yin, W., Zeng, Q., et al. Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor. Int. J. Biochem. Cell Biol. 44(9), 1410-1421 (2012).

    3. Dai, L., Perera, D.S., King, D.W., et al. Hemokinin-1 stimulates prostaglandin E2 production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenase. J. Pharmacol. Exp. Ther. 340(1), 27-36 (2012).

    4. Fu, C.Y., Zhao, Y.L., Dong, L., et al. In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice. Brain Behav. Immun. 22(6), 850-860 (2008).

    5. Kong, Z.-Q., Fu, C.-Y., Chen, Q., et al. Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats. Eur. J. Pharmacol. 590(1-3), 310-316 (2008).