A TRPM8 antagonist
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TC-I 2000

Item No. 35463

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide
CAS Number
1159996-20-9
Molecular Formula
C23H18F4N2O
Formula Weight
414.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: insolEthanol: 1 mg/mlPBS (pH 7.2): insol
λmax
234 nm
SMILES
O=C(N1CCC2=CC=CC=C2C1C3=CC=C(C(F)(F)F)C=C3)NC4=CC=C(C=C4)F
InChi Code
InChI=1S/C23H18F4N2O/c24-18-9-11-19(12-10-18)28-22(30)29-14-13-15-3-1-2-4-20(15)21(29)16-5-7-17(8-6-16)23(25,26)27/h1-12,21H,13-14H2,(H,28,30)
InChi Key
ADCDUDFEGFKKQH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $124

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    10 mg

    $234

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    25 mg

    $552

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    50 mg

    $979

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    Product Description

    TC-I 2000 is an antagonist of transient receptor potential melastatin 8 (TRPM8; IC50 = 53 nM for the rat receptor).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tamayo, N.A., Bo, Y., Gore, V., et al. Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J. Med. Chem. 55(4), 1593-1611 (2012).