A synthetic progestogen
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Melengestrol Acetate

Item No. 35471

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17-(acetyloxy)-6-methyl-16-methylene-pregna-4,6-diene-3,20-dione
CAS Number
2919-66-6
Synonyms
  • MGA
  • NSC 70968
Molecular Formula
C25H32O4
Formula Weight
396.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
λmax
286 nm
SMILES
CC(O[C@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@@]4(C(C(C)=C3)=CC(CC4)=O)C)([H])CC2)([H])CC1=C)C)C(C)=O)=O
InChi Code
InChI=1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1
InChi Key
UDKABVSQKJNZBH-DWNQPYOZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Melengestrol acetate is a synthetic progestogen and derivative of progesterone.1 It binds to progesterone receptors in rhesus monkey myometrial cytosolic preparations with high affinity relative to progesterone. Melengestrol acetate (0.1 mg/animal per day) suppresses estrus in rats.2 It reduces tumor growth in androgen-dependent and -independent prostate tumors in rats when administered at a dose of 10 mg/kg.3 Formulations containing melengestrol acetate have been used to increase weight gain, improve feed efficiency, and suppress estrus in heifer cattle.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Illingworth, D.V., Elsner, C., De La Cruz, K.D.G., et al. A specific progesterone receptor of myometrial cytosol from the rhesus monkey. J. Steroid Biochem. 8(2), 157-160 (1977).

    2. Chakraborty, P.K., Kliewer, R.H., and Hisaw Jr., F.L. Effect of melengestrol acetate on growth and reproduction in rats. J. Dairy Sci. 61(12), 1778-1781 (1978).

    3. Padilla, G.M., Yacullo, R.C., Padilla, J.J., et al. Melengestrol acetate and megestrol acetate are prostatic tumor inhibiting agents. Biochem. Cell Biol. 68(10), 1181-1188 (1990).