A neuroprotective ADNP-derived peptide
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Davunetide (acetate)

Item No. 35487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-asparaginyl-L-alanyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamine, acetate
Synonyms
  • AL-108
  • NAP
  • NAPVSIPQ
Molecular Formula
C36H60N10O12 • XC2H4O2
Formula Weight
824.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: insolPBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@H]1N(CCC1)C([C@H](C)NC([C@@H](N)CC(N)=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O.CC(O)=O
InChi Code
InChI=1S/C36H60N10O12.C2H4O2/c1-6-18(4)28(35(56)46-14-8-9-23(46)31(52)41-21(36(57)58)11-12-25(38)48)44-30(51)22(16-47)42-33(54)27(17(2)3)43-32(53)24-10-7-13-45(24)34(55)19(5)40-29(50)20(37)15-26(39)49;1-2(3)4/h17-24,27-28,47H,6-16,37H2,1-5H3,(H2,38,48)(H2,39,49)(H,40,50)(H,41,52)(H,42,54)(H,43,53)(H,44,51)(H,57,58);1H3,(H,3,4)/t18-,19-,20-,21-,22-,23-,24-,27-,28-;/m0./s1
InChi Key
FKFJZZGKZSKPFE-XVHDDEJMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $106

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    10 mg

    $191

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    25 mg

    $421

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    50 mg

    $631

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    Product Description

    Davunetide is a neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP).1 It promotes tubulin assembly in a cell-free assay when used at a concentration of 1 fM.2 Davunetide (1 fM) protects against cytotoxicity induced by tetrodotoxin (Item Nos. 14963 | 14964), a peptide derived from amyloid-β (Aβ), or zinc in isolated neonatal cerebral cortical cells.1,2 Intravitreal administration of davunetide (4 µl of a 100 µg/ml solution) inhibits increases in cleaved caspase-3 and decreases in Bcl-2 levels in retina isolated from streptozotocin-induced diabetic rats.3 It improves survival in a superoxide dismutase 1 mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS) when administered at 10 µg/animal.4 Davunetide prevents decreases in brain choline acetyltransferase (ChAT) activity and prevents memory deficits in the Morris water maze in an Apoe-/- mouse model of neurodegeneration.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bassan, M., Zamostiano, R., Davidson, A., et al. Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J. Neurochem. 72(3), 1283-1293 (1999).

    2. Divinski, I., Mittelman, L., and Gozes, I. A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication. The Journal of Biological Chemisty 279(27), 28531-28538 (2004).

    3. Scuderi, S., D'Amico, A.G., Castorina, A., et al. Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death. J. Mol. Neurosci. 54(3), 395-404 (2014).

    4. Jouroukhin, Y., Ostritsky, R., Assaf, Y., et al. NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transport. Neurobiol. Dis. 56, 79-94 (2013).