A 5-HT3 receptor agonist
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SR 57227A (hydrochloride)

Item No. 35499

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(6-chloro-2-pyridinyl)-4-piperidinamine, monohydrochloride
CAS Number
77145-61-0
Molecular Formula
C10H14ClN3 • HCl
Formula Weight
248.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 1 mg/ml
λmax
253 nm
SMILES
ClC1=NC(N2CCC(CC2)N)=CC=C1.Cl
InChi Code
InChI=1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
InChi Key
FUMINTAAUJUVMP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $94

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    10 mg

    $168

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    25 mg

    $371

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    50 mg

    $649

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    Product Description

    SR 57227A is an agonist of the serotonin (5-HT) receptor subtype 5-HT3.1 It selectively binds 5-HT3 receptors (IC50 = 2.8 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2, and 5-HT4 receptors (IC50s = >1,000 nM for all). SR 57227A (20 µM) induces contractions in isolated guinea pig ileum, an effect that can be reversed by the 5-HT3 antagonist tropisetron (Item No. 21240). Intrastriatal administration of SR 57227A (1 µg/animal) induces contralateral turning behavior in mice. It reduces immobility time in the forced swim test in rats (ED50 = 7.6 mg/kg), as well as reduces the number of escape failures in a rat model of learned helplessness and the duration of fighting in a mouse model of isolation-induced aggression.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bachy, A., Héaulme, M., Giudice, A., et al. SR 57227A: A potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur. J. Pharmacol. 237(2-3), 299-309 (1993).

    2. Poncelet, M., Pério, A., Simiand, J., et al. Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J. Neural Transm. Gen. Sect. 102(2), 83-90 (1995).