A dynein inhibitor
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Dynarrestin

Item No. 35527

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-5-thiazolecarboxylic acid, ethyl ester
CAS Number
2222768-84-3
Molecular Formula
C22H23F2N3O2S
Formula Weight
431.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 14 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.30 mg/ml
λmax
236, 281, 324, 367 nm
SMILES
O=C(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(NC3=C(F)C=C(F)C=C3)S1)OCC
InChi Code
InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)
InChi Key
UZNNDDDSGCMQOQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Dynarrestin is an inhibitor of dynein 1 and -2.1 It inhibits dynein 1-dependent microtubule gliding (IC50 = 5 µM) and dynein 2-dependent intraflagellar transport in mIMCD-3 inner medullary collecting duct cells when used at concentrations of 0.125 and 1.25 µM. Dynarrestin decreases the number of cells in metaphase, anaphase, or telophase in asynchronous COS-7 cells (IC50 = 6.25 µM). It inhibits the proliferation of primary Ptch+/- murine medulloblastoma cells (IC50 = 0.068 µM) and the expression of GLI1 in KYSE-180 esophageal squamous cell carcinoma cells stimulated with the smoothened (Smo) agonist purmorphamine (Item No. 10009634; IC50 = 0.21 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Höing, S., Yeh, T.-Y., Baumann, M., et al. Dynarrestin, a novel inhibitor of cytoplasmic dynein. Cell Chem. Biol. 25(4), 357-369 (2018).