A PDE3 and PDE4 inhibitor
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ICI 63197

Item No. 35538

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
CAS Number
27277-00-5
Molecular Formula
C9H13N5O
Formula Weight
207.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 10 mg/mLEthanol: Slightly solublePBS (pH 7.2): 0.2 mg/mL
λmax
224, 307 nm
SMILES
O=C1C(C)=CN2N=C(N)N=C2N1CCC
InChi Code
InChI=1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)
InChi Key
UQDVRVNMIJAGRK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $110

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    100 mg

    $178

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    250 mg

    $358

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    500 mg

    $660

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    Product Description

    ICI 63197 is an inhibitor of phosphodiesterase 3 (PDE3) and PDE4 (Kis = 9 and 10 µM, respectively).1 It is selective for PDE3 and PDE4 over PDE1 and PDE2 (Kis = 487 and >1,000 µM, respectively). ICI 63197 inhibits acetylcholine-induced bronchospasm in isolated guinea pig lungs and histamine-induced bronchospasm in conscious guinea pigs.2 It decreases motor activity and rectal temperature and induces forepaw shaking, head twitches, and grooming in rats in a dose-dependent manner.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoey, M., and Houslay, M.D. Identification and selective inhibition of four distinct soluble forms of cyclic nucleotide phosphodiesterase activity from kidney. Biochem. Pharmacol. 40(2), 193-202 (1990).

    2. Davies, G.E. Antibronchoconstrictor activity of two new phosphodiesterase inhibitors, a triazolopyrazine (ICI 58 301) and a triazolopyrimidine (ICI 63 197). J. Pharm. Pharmacol. 25(9), 681-689 (1973).

    3. Wachtel, H. Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors. Psychopharmacology (Berl.) 77(4), 309-316 (1982).