A neuromodulatory agent
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2-Aminotetralin

Item No. 35544

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-2-naphthalenamine
CAS Number
2954-50-9
Synonyms
  • 2-AT
  • Tetralin-2-amine
Molecular Formula
C10H13N
Formula Weight
147.2
Purity
≥95%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
NC1CC2=CC=CC=C2CC1
InChi Code
InChI=1S/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-4,10H,5-7,11H2
InChi Key
LCGFVWKNXLRFIF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $48

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    250 mg

    $112

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    500 mg

    $179

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    1 g

    $236

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    Product Description

    2-Aminotetralin is a neuromodulatory agent.1,2,3 It inhibits serotonin (5-HT) and norepinephrine reuptake in rat brain when administered at a dose of 39.4 mg/kg.1 2-Aminotetralin induces hypothermia in rats when administered by intracisternal or intraperitoneal injection, but implantation of 2-aminotetralin crystals in the medial preoptic area of the hypothalamus induces hyperthermia in rats.2 It substitutes for (+)-amphetamine in rats in a two-lever drug discrimination test in a dose-dependent manner.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bruinvels, J. Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brain. Br. J. Pharmacol. 42(2), 281-286 (1971).

    2. Bruinvels, J., and Kemper, G.C. Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat. Br. J. Pharmacol. 43(1), 1-9 (1971).

    3. Oberlender, R., and Nichols, D.E. Structural variation and (+)-amphetamine-like discriminative stimulus properties. Pharmacol. Biochem. Behav. 38(3), 581-586 (1991).