A humanin peptide mimetic
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Product Type

Biochemicals

Research Area

Neuroscience

UCLA gp130 2

Item No. 35551

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-fluorophenyl)-4-phenyl-2-thiazolamine
CAS Number
339303-87-6
Molecular Formula
C15H11FN2S
Formula Weight
270.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 3 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): insol
λmax
243, 278 nm
SMILES
FC1=CC=C(NC2=NC(C3=CC=CC=C3)=CS2)C=C1
InChi Code
InChI=1S/C15H11FN2S/c16-12-6-8-13(9-7-12)17-15-18-14(10-19-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)
InChi Key
RSKMQDIAPGOWDL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $97

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    10 mg

    $174

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    25 mg

    $412

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    50 mg

    $676

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    Product Description

    UCLA gp130 2 is a humanin peptide mimetic.1 It inhibits NMDA-induced lactate dehydrogenase (LDH) release, a marker of cytotoxicity, in primary mouse hippocampal neurons when used at a concentration of 10 µM, an effect that can be reversed by the gp130 inhibitor SC144 (Item No. 29714).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alam, M.P., Bilousova, T., Spilman, P., et al. A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-Induced neurotoxicity. ACS Chem. Neurosci. 9(3), 462-468 (2018).