An internal standard for the quantification of 21-deoxycortisol
Related Products
Unlabeled Version(s)
3087321-Deoxycortisol
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

21-Deoxycortisol-d8

Item No. 35556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11,17-dihydroxy-pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8
CAS Number
2479914-04-8
Synonyms
  • 21-Dehydrohydrocortisone-d8
Molecular Formula
C21H22D8O4
Formula Weight
354.5
Purity
≥99% deuterated forms (d1-d8)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
241 nm
SMILES
C[C@@]12[C@](CC[C@]2(O)C(C([2H])([2H])[2H])=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)C
InChi Code
InChI=1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1/i1D3,4D2,6D2,10D
InChi Key
LCZBQMKVFQNSJR-ZERYXUNYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $263

    Add

    5 mg

    $1,052

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    21-Deoxycortisol-d8 is intended for use as an internal standard for the quantification of 21-deoxycortisol (Item No. 30873) by GC- or LC-MS. 21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal gland via 11-hydroxylation by 11β-hydroxylase.1,2 Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations in CYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fiet, J., Villette, J.-M., Galons, H., et al. The application of a new highly-sensitive radioimmunoassay for plasma 21-deoxycortisol to the detection of steroid-21-hydroxylase deficiency. Ann. Clin. Biochem. 31(Pt. 1), 56-64 (1994).

    2. Cristoni, S., Cuccato, D., Sciannamblo, M., et al. Analysis of 21-deoxycortisol, a marker of congenital adrenal hyperplasia, in blood by atmospheric pressure chemical ionization and electrospray ionization using multiple reaction monitoring. Rapid Commun. Mass Spectrom. 18(1), 77-82 (2004).