An internal standard for the quantification of carazolol
Related Products
Unlabeled Version(s)
18628Carazolol
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Carazolol-d7

Item No. 35560

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-((9H-carbazol-4-yl)oxy)-3-((propan-2-yl-d7)amino)propan-2-ol
CAS Number
1173021-02-7
Synonyms
  • (±)-Carazolol-d7
Molecular Formula
C18H15D7N2O2
Formula Weight
305.4
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightlyMethanol: very slightly
SMILES
OC(CNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])COC1=C(C(C=CC=C2)=C2N3)C3=CC=C1
InChi Code
InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3/i1D3,2D3,12D
InChi Key
BQXQGZPYHWWCEB-QLWPOVNFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $62

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    5 mg

    $214

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    10 mg

    $395

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    25 mg

    $833

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    Product Description

    Carazolol-d7 is intended for use as an internal standard for the quantification of carazolol (Item No. 18628) by GC- or LC-MS. Carazolol is a β-adrenergic receptor (β-AR) ligand (Kds = 0.2, 0.03, and 4.47 nM for the human β1-, β2-, and β3-ARs, respectively).1 It reduces epinephrine-induced increases in mean arterial blood pressure and heart rate in conscious pigs when administered at a dose of 10 µg/kg.2 Carazolol has been found in wastewater effluent.3 Formulations containing carazolol have been used to reduce stress in livestock during transport.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baker, J.G. The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors. Br. J. Pharmacol. 160(5), 1048-1061 (2010).

    2. Gregory, N.G., and Wilkins, L.J. The effect of carazolol on the cardiovascular responses to adrenaline in stress sensitive pigs. Vet. Res. Commun. 5(3), 277-283 (1982).

    3. Ternes, T.A. Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32(11), 3245-3260 (1998).