Tulobuterol (hydrochloride)

Tulobuterol is a long-acting agonist of the β₂-adrenergic receptor (β₂-AR).¹ It binds to the bovine skeletal muscle β₂-AR (K_d = 0.13 µM). Transdermal administration of tulobuterol (6 and 12 mg/kg) decreases total leukocyte infiltration into the bronchoalveolar lavage fluid (BALF) in a mouse model of allergic asthma induced by ovalbumin.² It also inhibits rhinovirus replication in infected primary human tracheal epithelial cells when used at a concentration of 0.1 µM, an effect that can be reversed by the β₂-AR antagonist ICI 118551 (Item No. 15591).³ Formulations containing tulobuterol have been used in the treatment of asthma.

WARNING This product is not for human or veterinary use.

1. IJzerman, A.P., Bultsma, T., and Timmerman, H. Quantitative evaluation of the β₂-adrenoceptor intrinsic activity of N-tert-butylphenylethanolamines. J. Med. Chem. 29(4), 549-554 (1986).

2. Fu, L., Guan, J., Zhang, Y., et al. Tulobuterol patch alleviates allergic asthmic inflammation by blockade of Syk and NF-κB activation in mice. Oncotarget 9(15), 12154-12163 (2018).

3. Yamaya, M., Nishimura, H., Nadine, L., et al. Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Physiol. Rep. 1(3), e00041 (2013).