An antibiotic
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Hygromycin A

Item No. 35565

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propen-1-yl]amino]-1,2-O-methylene-D-neo-inositol
CAS Number
6379-56-2
Synonyms
  • (−)-Hygromycin A
  • Totomycin
Molecular Formula
C23H29NO12
Formula Weight
511.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 12 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
218, 274 nm
SMILES
O[C@H]1[C@@]2([H])[C@@](OCO2)([H])[C@@H]([C@H]([C@H]1NC(/C(C)=C/C3=CC(O)=C(C=C3)O[C@H]4[C@@H](O)[C@H](O)[C@@H](C(C)=O)O4)=O)O)O
InChi Code
InChI=1S/C23H29NO12/c1-8(22(32)24-13-14(27)16(29)21-20(15(13)28)33-7-34-21)5-10-3-4-12(11(26)6-10)35-23-18(31)17(30)19(36-23)9(2)25/h3-6,13-21,23,26-31H,7H2,1-2H3,(H,24,32)/b8-5+/t13-,14+,15-,16-,17+,18+,19-,20+,21-,23-/m1/s1
InChi Key
YQYJSBFKSSDGFO-IIHALWDASA-N
Origin
Bacterium/Streptomyces hygro
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Hygromycin A is an antibiotic originally isolated from S. hygroscopicus.1 It is active against numerous spirochete bacteria, including T. pallidum, L. biflexa, and four strains of B. burgdorferi (MICs = 0.03-4 µg/ml for all). Hygromycin A binds to the peptidyl transferase center (PTC) in the 70S ribosomal subunit to inhibit protein synthesis. It completely eliminates bacterial infection in skin biopsies from B. burgdorferi-infected mice in a model of acute Lyme disease when administered at doses ranging from 50 to 250 mg/kg twice per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leimer, N., Wu, X., Imai, Y., et al. A selective antibiotic for Lyme disease. Cell 184(21), 5405-5418.e5416 (2021).