A synthetic intermediate
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AZD 9291DA

Item No. 35570

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine
CAS Number
1421372-66-8
Synonyms
  • Osimertinib analog
Molecular Formula
C25H31N7O
Formula Weight
445.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 0.2 mg/ml
λmax
218, 273, 331 nm
SMILES
NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(CCN(C)C)C
InChi Code
InChI=1S/C25H31N7O/c1-30(2)12-13-31(3)23-15-24(33-5)21(14-19(23)26)29-25-27-11-10-20(28-25)18-16-32(4)22-9-7-6-8-17(18)22/h6-11,14-16H,12-13,26H2,1-5H3,(H,27,28,29)
InChi Key
HTNTZPBKKCORTP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $316

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    Product Description

    AZD 9291DA is a synthetic intermediate that has been used in the synthesis of the mutant EGFR inhibitor AZD 9291 (Item No. 16237).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Finlay, M.R., Anderton, M., Ashton, S., et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J. Med. Chem. 57(20), 8249-8267 (2014).