A RARγ agonist
Related Products
Enantiomer(s)
29380BMS 189961
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BMS 270394

Item No. 35576

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-fluoro-4-[[(2R)-2-hydroxy-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)acetyl]amino]-benzoic acid
CAS Number
262433-54-5
Molecular Formula
C23H26FNO4
Formula Weight
399.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/ml
SMILES
OC(C1=CC(F)=C(NC([C@H](O)C2=CC(C(C)(C)CCC3(C)C)=C3C=C2)=O)C=C1)=O
InChi Code
InChI=1S/C23H26FNO4/c1-22(2)9-10-23(3,4)16-11-13(5-7-15(16)22)19(26)20(27)25-18-8-6-14(21(28)29)12-17(18)24/h5-8,11-12,19,26H,9-10H2,1-4H3,(H,25,27)(H,28,29)/t19-/m1/s1
InChi Key
AANFHDFOMFRLLR-LJQANCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $124

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    5 mg

    $552

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    Product Description

    BMS 270394 is an agonist of retinoic acid receptor γ (RARγ; EC50 = 30 nM in a transactivation assay) and the active enantiomer of BMS 189961 (Item No. 29380).1 It is selective for RARγ over RARβ (EC50 = 400 nM) and is inactive at RARα. BMS 270394 synergizes with paclitaxel (Item No. 10461) to inhibit the growth of MCF-7 breast and OVCAR-3 ovarian cancer, as well as SqCC/Y1 head and neck squamous cell carcinoma, cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Klaholz, B.P., Mitschler, A., Belema, M., et al. Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc. Natl. Acad. Sci. USA 97(12), 6322-6327 (2000).

    2. Vivat-Hannah, V., You, D., Rizzo, C., et al. Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel). Cancer Res. 61(24), 8703-8711 (2001).