A tetrahydroberberine alkaloid
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Product Categories

Product Type

Biochemicals
Natural Products
Alkaloids

Research Area

Neuroscience

D-Tetrahydropalmatine

Item No. 35577

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,8,13,13aR-tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine
CAS Number
3520-14-7
Synonyms
  • (+)-Corydalis B
  • (+)-Tetrahydropalmatine
  • (R)-Tetrahydropalmatine
  • D-THP
Molecular Formula
C21H25NO4
Formula Weight
355.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleEthanol: slightly solubleMethanol: slightly soluble
SMILES
COC1=C(OC)C2=C(C=C1)C[C@]3([H])C4=CC(OC)=C(OC)C=C4CCN3C2
InChi Code
InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m1/s1
InChi Key
AEQDJSLRWYMAQI-QGZVFWFLSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $37

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    10 mg

    $62

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    25 mg

    $118

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    50 mg

    $216

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    Product Description

    D-Tetrahydropalmatine is a tetrahydroberberine alkaloid that has been found in Corydalis.1 In vivo, D-Tetrahydropalmatine (32 mg/kg) reverses apomorphine-induced inhibition of dopaminergic firing in the substantia nigra pars compacta (SNC) in paralyzed rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liao, J., Liang, W.-Z., and Tu, G.-S. Isolation and identification of eleven tertiary alkaloids in Corydalis decumbens. J. Chin. Pharma. Sci. 4(2), 57-61 (1995).

    2. Sun, B.C., Huang, K.X., and Jin, G.Z. Comparison of effects of tetrahydropalmatine enantiomers on firing activity of dopamine neurons in substantia nigra pars compacta. Zhongguo Yao Li Xue Bao 13(4), 292-297 (1992).