A two-photon fluorescent probe for H2Sn
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PSP

Item No. 35589

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-6-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)naphthalen-2-yl 2-fluoro-5-nitrobenzoate
CAS Number
3030735-86-2
Molecular Formula
C30H22FN3O4
Formula Weight
507.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/ml
λmax
220, 251, 406 nm
SMILES
O=C(OC1=CC(C=CC(/C=C/C2=C/C(CC(C)(C)C2)=C(C#N)/C#N)=C3)=C3C=C1)C4=C(F)C=CC([N+]([O-])=O)=C4
InChi Code
InChI=1S/C30H22FN3O4/c1-30(2)15-20(12-23(16-30)24(17-32)18-33)4-3-19-5-6-22-13-26(9-7-21(22)11-19)38-29(35)27-14-25(34(36)37)8-10-28(27)31/h3-14H,15-16H2,1-2H3/b4-3+
InChi Key
XADDYEFXVWMUAY-ONEGZZNKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

    $176

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    50 mg

    $392

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    100 mg

    $735

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    Product Description

    PSP is a two-photon fluorescent probe for hydrogen polysulfide (H2Sn), a reactive sulfur species (RSS) formed during ferroptosis.1 Upon reaction with H2Sn, the 2-fluoro-5-nitro-benzoate quenching group of PSP is removed, resulting in the release of a near-infrared emitting product. PSP is selective for H2Sn over a panel of reactive oxygen species (ROS), reactive nitrogen species (RNS), metal ions, and sulfur-containing ions. It has been used to detect H2Sn in live cells and tumor spheroids in vitro.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Di, X., Ge, C., Liu, Y., et al. Monitoring hydrogen polysulfide during ferroptosis with a two-photon fluorescent probe. Talanta 232, 122467 (2021).