An anticancer agent
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Indium (III) thiosemicarbazone 5b

Item No. 35601

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(OC-6-43)-dichloro[N,N-dimethyl-2-[(2-pyridinyl-κN)methylene]hydrazinecarbothioamide-κN2,κS]methoxy-indium
CAS Number
2345755-20-4
Molecular Formula
C10H15Cl2InN4OS
Formula Weight
425.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:2): 0.30 mg/mlDMSO: 1 mg/mlEthanol: Slightly Soluble
λmax
302, 411 nm
SMILES
[Cl-][In+3]12([O-]C)([S]=C([N](C)C)[NH][N]1=CC3=CC=CC=[N]32)[Cl-]
InChi Code
InChI=1S/C9H12N4S.CH3O.2ClH.In/c1-13(2)9(14)12-11-7-8-5-3-4-6-10-8;1-2;;;/h3-7H,1-2H3,(H,12,14);1H3;2*1H;/q;-1;;;+3/p-2/b11-7+;;;;
InChi Key
VNKHZVLDFDLQKI-UTUIWUMXSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Indium (III) thiosemicarbazone 5b is an anticancer agent.1 It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11, and 8.95 µM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo, indium (III) thiosemicarbazone 5b (2.5 µmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jiang, M., Chu, Y., Yang, T., et al. Developing a novel indium(III) agent based on liposomes to overcome cisplatin-induced resistance in breast cancer by multitargeting the tumor microenvironment components. J. Med. Chem. 64(19), 14587-14602 (2021).