A potential impurity found in commercial preparations of L-thyroxine
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L-Thyroxine-N-methylamide

Item No. 35606

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αS-amino-4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-N-methyl-benzenepropanamide
CAS Number
2088032-52-2
Molecular Formula
C16H14I4N2O3
Formula Weight
789.9
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.20 mg/ml
λmax
224 nm
SMILES
IC(C=C(C=C1I)C[C@H](N)C(NC)=O)=C1OC2=CC(I)=C(C(I)=C2)O
InChi Code
InChI=1S/C16H14I4N2O3/c1-22-16(24)13(21)4-7-2-11(19)15(12(20)3-7)25-8-5-9(17)14(23)10(18)6-8/h2-3,5-6,13,23H,4,21H2,1H3,(H,22,24)/t13-/m0/s1
InChi Key
KRYBBJJOQJVIIZ-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $32

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    10 mg

    $61

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    25 mg

    $102

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    50 mg

    $186

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    Product Description

    L-Thyroxine-N-methylamide is a potential impurity found in commercial preparations of the synthetic thyroid hormone form L-thyroxine (Item No. 14116).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Panmanad, D., Joshi, M.S., Patil, R., et al. Synthesis and characterization of potential impurities in levothyroxine. Chem. Sci. Trans. 5(4), 1082-1089 (2016).