A triterpenoid with reverse transcriptase inhibitory and anti-inflammatory activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tirucallol

Item No. 35623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,13α,14β,17α,20S)-lanosta-8,24-dien-3-ol
CAS Number
514-46-5
Synonyms
  • NSC 403164
  • (+)-Tirucallol
Molecular Formula
C30H50O
Formula Weight
426.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: solubleDMSO: 10mM
SMILES
C[C@@]12C3=C(CC[C@]1([C@](CC2)([H])[C@@H](C)CC/C=C(C)\C)C)[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC3)C
InChi Code
InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25-,26-,28+,29-,30+/m0/s1
InChi Key
CAHGCLMLTWQZNJ-HGKXYCPESA-N
Origin
Plant/Euphorbia ebracteolata Hayata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $156

    Add

    1 mg

    $279

    Add

    5 mg

    $1,005

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Tirucallol is a triterpenoid that has been found in Camellia and has reverse transcriptase inhibitory and anti-inflammatory activities.1,2 It inhibits HIV-1 reverse transcriptase (IC50 = 3.8 µM).1 Tirucallol (25, 50, and 100 µM) reduces nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated isolated mouse peritoneal macrophages.2 Topical application of tirucallol (0.25, 0.5, and 1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akihisa, T., Ogihara, J., Kato, J., et al. Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase. Lipids 36(5), 507-512 (2001).

    2. Fernandez-Arche, A., Saenz, M.T., Arroyo, M., et al. Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. Phytomedicine 17(2), 146-148 (2010).