A triterpenoid saponin with hepatoprotective activity
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Isomer(s)
34202Hederacoside D
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Dipsacoside B

Item No. 35624

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4α)-3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-olean-12-en-28-oic acid, 6-O-β-D-glucopyranosyl-β-D-glucopyranosyl
CAS Number
33289-85-9
Synonyms
  • Glycoside L-G3
  • Tauroside G3
Molecular Formula
C53H86O22
Formula Weight
1075.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mLDMSO: 16 mg/mLEthanol: 5 mg/mLPBS (pH 7.2): 5 mg/mL
SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]2O)O)O)O[C@H]2OC([C@]34[C@](CC(C)(CC4)C)([H])C5=CC[C@@]([C@@]6([C@@]([C@@](C)([C@H](CC6)O[C@H]7[C@@H]([C@H]([C@H](CO7)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)CO)([H])CC9)C)([H])[C@]9(C)[C@@]5(CC3)C)=O
InChi Code
InChI=1S/C53H86O22/c1-23-32(57)36(61)40(65)44(70-23)74-42-33(58)26(56)20-68-46(42)73-31-11-12-49(4)29(50(31,5)22-55)10-13-52(7)30(49)9-8-24-25-18-48(2,3)14-16-53(25,17-15-51(24,52)6)47(67)75-45-41(66)38(63)35(60)28(72-45)21-69-43-39(64)37(62)34(59)27(19-54)71-43/h8,23,25-46,54-66H,9-22H2,1-7H3/t23-,25-,26-,27+,28+,29+,30+,31-,32-,33-,34+,35+,36+,37-,38-,39+,40+,41+,42+,43+,44-,45-,46-,49-,50-,51+,52+,53-/m0/s1
InChi Key
GFPLPBCJRRNZHM-ICUGHKHQSA-N
Origin
Plant/Lonicera confusa DC
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $57

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Dipsacoside B is a triterpenoid saponin that has been found in Lonicera and has hepatoprotective activity.1,2 It enhances acetaminophen-induced autophagy and inhibits acetaminophen-induced apoptosis in HepG2 cells when used at a concentration of 0.5 µM.2 Dipsacoside B (50 mg/kg) increases survival in a mouse model of acute liver failure induced by acetaminophen (Item No. 10024).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, R., Min, K., Wang, Y., et al. Rapid semi-quantitative analysis of hemolytic triterpenoid saponins in Lonicerae Flos crude drugs and preparations by paper spray mass spectrometry. Talanta 239, 123148 (2022).

    2. Chen, S., Li, M., Jiang, W., et al. The role of Neu1 in the protective effect of dipsacoside B on acetaminophen-induced liver injury. Ann. Transl. Med. 8(13), 823 (2020).