An inhibitor of the protein-peptide interaction between PRMT5 and PBM
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BRD0639

Item No. 35625

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-1(6H)-pyridazineacetamide
CAS Number
2760881-74-9
Molecular Formula
C21H22ClN5O4S
Formula Weight
475.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/ml
λmax
211, 252 nm
SMILES
ClC(C=NN1[C@@H](C)C(NC2=CC=C(C)C(S(NCCC3=NC=CC=C3)(=O)=O)=C2)=O)=CC1=O
InChi Code
InChI=1S/C21H22ClN5O4S/c1-14-6-7-18(26-21(29)15(2)27-20(28)11-16(22)13-24-27)12-19(14)32(30,31)25-10-8-17-5-3-4-9-23-17/h3-7,9,11-13,15,25H,8,10H2,1-2H3,(H,26,29)/t15-/m0/s1
InChi Key
BXDCFRRDENJUJM-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $54

    Add

    5 mg

    $162

    Add

    10 mg

    $270

    Add

    25 mg

    $472

    Add
    Product Description

    BRD0639 is an inhibitor of the protein-peptide interaction between protein arginine methyltransferase 5 (PRMT5) and PRMT5 binding motif (PBM; IC50 = 13.8 µM), a conserved peptide motif contained in PRMT5 substrate adaptor proteins (SAPs) that mediates SAP binding to PRMT5.1 It induces the formation of PRMT5 adducts in cells (EC50 = 3 µM) and disrupts complex formation between PRMT5 and the SAP RIO kinase 1 (RIOK1) in permeabilized cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McKinney, D.C., McMillan, B.J., Ranaghan, M.J., et al. Discovery of a first-in-class inhibitor of the PRMT5−substrate adaptor interaction. J. Med. Chem. 64(15), 11148-11168 (2022).