A triterpene with anti-inflammatory and hepatoprotective activities
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Alisol F

Item No. 35627

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8α,9β,11β,14β,16β,23S,24R)-16,23-epoxy-11,24,25-trihydroxy-dammar-13(17)-en-3-one
CAS Number
155521-45-2
Molecular Formula
C30H48O5
Formula Weight
488.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: solubleChloroform: solubleDichloromethane: solubleDMSO: solubleEthyl Acetate: soluble
SMILES
C[C@@]12[C@@]3([C@]([C@H](CC1=C4[C@](O[C@](C[C@H]4C)([H])[C@@H](O)C(C)(O)C)([H])C2)O)([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC3)C)C
InChi Code
InChI=1S/C30H48O5/c1-16-13-19(25(33)27(4,5)34)35-20-15-30(8)17(23(16)20)14-18(31)24-28(6)11-10-22(32)26(2,3)21(28)9-12-29(24,30)7/h16,18-21,24-25,31,33-34H,9-15H2,1-8H3/t16-,18+,19+,20+,21+,24+,25-,28+,29+,30+/m1/s1
InChi Key
YNKJSQIXVXWFBK-SLGDLKFASA-N
Origin
Plant/Alisma plantago-aquatica tubers
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $98

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    5 mg

    $367

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    10 mg

    $587

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    Product Description

    Alisol F is a triterpene that has been found in A. orientale and has anti-inflammatory and hepatoprotective activities.1,2 It reduces levels of inducible nitric oxide synthase (iNOS) and COX-2 and the production of TNF-α, IL-6,and IL-1β in LPS-stimulated RAW 264.7 cells.1 Alisol F (20 mg/kg) reduces plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, hepatic fibrosis, and hepatic levels of phosphorylated ERK in a mouse model of LPS/D-galactosamine-induced acute liver injury.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bi, X., Wang, P., Ma, Q., et al. Anti-inflammatory activities and liver protection of alisol F and 25-anhydroalisol F through the inhibition of MAPK, STAT3, and NF-κB activation in vitro and in vivo. Molecules 22(6), 951 (2017).

    2. Choi, E., Jang, E., and Lee, J.-H. Pharmacological activities of Alisma orientale against nonalcoholic fatty liver disease and metabolic syndrome: Literature review. Evid. Based Complement. Alternat. Med. 2943162 (2019).