A prenylated xanthone with anticancer activity
Related Products
Isomer(s)
26675γ-Mangostin
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Product Type

Biochemicals
Natural Products

Research Area

Cancer
Autophagy
Cell Death
Apoptosis

Gartanin

Item No. 35631

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3,5,8-tetrahydroxy-2,4-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number
33390-42-0
Synonyms
  • NSC 692946
Molecular Formula
C23H24O6
Formula Weight
396.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
λmax
224, 259, 284, 351 nm
SMILES
O=C1C2=C(C=CC(O)=C2OC3=C(C/C=C(C)\C)C(O)=C(C/C=C(C)\C)C(O)=C31)O
InChi Code
InChI=1S/C23H24O6/c1-11(2)5-7-13-19(26)14(8-6-12(3)4)22-18(20(13)27)21(28)17-15(24)9-10-16(25)23(17)29-22/h5-6,9-10,24-27H,7-8H2,1-4H3
InChi Key
OJXQLGQIDIPMTE-UHFFFAOYSA-N
Origin
Plant/Garcinia mangostana stem barks
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

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    10 mg

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    25 mg

    $722

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    Cayman Chemical
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    Product Description

    Gartanin is a prenylated xanthone that has been found in G. mangostana and has anticancer activity.1,2 It inhibits the growth of T24, UM-UC-3, HT-1376, and TCCSUP bladder cancer cells (IC50s = 4.1-18.1 µM).1 Gartanin (10 and 50 µM) increases the number of LC3 puncta, a marker of autophagy, in T24 cells expressing pEGFP-LC3, as well as induces apoptosis in T24 and RT4 cells. It binds to NEDD8-activating enzyme (NAE) and inhibits NEDDylation of cullin 1 and ubiquitin-conjugating enzyme 12 (UBC12) in PC3 and 22Rv1 prostate cancer cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Z., Antalek, M., Nguyen, L., et al. The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines. Nutr. Cancer 65 Suppl. 1 (0 1), 68-77 (2013).

    2. Pham, V., Rendon, R., Le, V.X., et al. Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy. Mol. Carcinog. 59(2), 193-201 (2020).