A polyphenol flavonoid with diverse biological activities
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Salvigenin

Item No. 35632

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
19103-54-9
Synonyms
  • 5-hydroxy-4',6,7-Trimethoxyflavone
  • 7-O-Methylpectolinarigenin
  • Psathyrotin
Molecular Formula
C18H16O6
Formula Weight
328.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: solubleChloroform: solubleDichloromethane: solubleDMSO: solubleEthyl Acetate: soluble
SMILES
O=C1C=C(C2=CC=C(C=C2)OC)OC3=CC(OC)=C(C(O)=C13)OC
InChi Code
InChI=1S/C18H16O6/c1-21-11-6-4-10(5-7-11)13-8-12(19)16-14(24-13)9-15(22-2)18(23-3)17(16)20/h4-9,20H,1-3H3
InChi Key
QCDYOIZVELGOLZ-UHFFFAOYSA-N
Origin
Plant/Salvia japonica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $70

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    5 mg

    $307

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    10 mg

    $544

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    Cayman Chemical
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    Product Description

    Salvigenin is a polyphenol flavonoid originally found in Alnus japonica with diverse biological activities.1,2,3 It inhibits hydrogen peroxide-induced apoptosis and reduces the generation of reactive oxygen species (ROS) in SH-SY5Y human neuroblastoma cells when used at a concentration of 25 µM.2 Salvigenin (25 and 50 µM) decreases cleaved caspase-3 levels and the Bax/B cell lymphoma 2 (Bcl-2) ratio in SH-SY5Y cells. It reduces the viability of MCF-7 human breast cancer cells in a concentration-dependent manner.3 Salvigenin (3.65-9.68 µg/mouse per day) enhances the delayed-type hypersensitivity (DTH) response to sheep red blood cells in mice. It increases the production of IFN-γ induced by lysate antigens in isolated mouse splenocytes. Salvigenin (9.68 µg/mouse per day) reduces tumor growth in a spontaneous mouse mammary tumor (SMMT) model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wollenweber, E. Flavonoids from Alnus crispa, A. japonica, A. koehnei and A. sinuata. Phytochemistry 13(10), 2318-2319 (1974).

    2. Rafatian, G., Khodagholi, F., Farimani, M.M., et al. Increase of autophagy and attenuation of apoptosis by Salvigenin promote survival of SH-SY5Y cells following treatment with H2O2. Mol. Cell. Biochem. 371(1-2), 9-22 (2012).

    3. Noori, S., Hassan, Z.M., Yaghmaei, B., et al. Antitumor and immunomodulatory effects of salvigenin on tumor bearing mice. Cell. Immunol. 286(1-2), 16-21 (2013).