An oligosaccharide ester with antidepressant- and anxiolytic-like activities
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3,6′-Disinapoylsucrose

Item No. 35640

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-O-[(2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl α-D-glucopyranoside 6-[(2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propenoate]
CAS Number
139891-98-8
Synonyms
  • DISS
Molecular Formula
C34H42O19
Formula Weight
754.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
240, 333 nm
SMILES
OC[C@@]1([C@H]([C@@H]([C@H](O1)CO)O)OC(/C=C/C2=CC(OC)=C(C(OC)=C2)O)=O)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)COC(/C=C/C4=CC(OC)=C(C(OC)=C4)O)=O
InChi Code
InChI=1S/C34H42O19/c1-45-18-9-16(10-19(46-2)26(18)39)5-7-24(37)49-14-23-28(41)30(43)31(44)33(50-23)53-34(15-36)32(29(42)22(13-35)52-34)51-25(38)8-6-17-11-20(47-3)27(40)21(12-17)48-4/h5-12,22-23,28-33,35-36,39-44H,13-15H2,1-4H3/b7-5+,8-6+/t22-,23-,28-,29-,30+,31-,32+,33-,34+/m1/s1
InChi Key
FHIJMQWMMZEFBL-OPSYHMPNSA-N
Origin
Plant/Polygala tenuifolia
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    10 mg

    $242

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    25 mg

    $492

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    50 mg

    $633

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    Product Description

    3,6′-Disinapoylsucrose is an oligosaccharide ester that has been found in P. tenufolia and has antidepressant- and anxiolytic-like activities.1,2 It prevents increases in serum cortisol levels, serum superoxide dismutase (SOD) activity, and brain monoamine oxidase A (MAO-A) and MAO-B levels, as well as decreases serum malondialdehyde (MDA) levels, in a rat model of chronic mild stress.1 3,6′-Disinapoylsucrose (20 mg/kg) increases sucrose consumption in the sucrose preference test, indicating antidepressant-like activity, in the same model. It increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at doses ranging from 3 to 12 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, Y., Liu, M., Liu, P., et al. Possible mechanism of the antidepressant effect of 3,6'-disinapoyl sucrose from Polygala tenuifolia Willd. J. Pharm. Pharmacol. 63(6), 869-874 (2011).

    2. Zhang, J., Xie, J., Liang, Y., et al. Anxiolytic effects, metabolism and plasma pharmacokinetics of 3,6'-disinapoylsucrose. Biomed. Pharmacother. 149, 112913 (2022).