Linderalactone

Linderalactone is a sesquiterpene lactone that has been found in L. aggregate and has anticancer and antioxidant activities.^1,2,3 It is an inhibitor of α-glucosidase (IC₅₀ = 12.72 µM).¹ Linderalactone inhibits the proliferation of A549 lung cancer cells (IC₅₀ = 15 µM).² It also induces apoptosis and cell cycle arrest at the G₂/M phase and reduces the levels of unphosphorylated and phosphorylated JAK1, JAK2, STAT1, and STAT2 in A549 cells in a concentration-dependent manner. Linderalactone reduces hydrogen peroxide-induced increases in cell death in HepG2 cells (EC₅₀ = 98 µM).³

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1. Jani, N.A., Sirat, H.M., Ahmad, F., et al. New sesquiterpene dilactone and β -carboline alkaloid and the α -glucosidase inhibitory activity of selected phytochemicals from Neolitsea cassia (L.) Kosterm. Nat. Prod. Res. 36(16), 4061-4069 (2021).

2. Deng, Y., and Ya, L. Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins, G₂/M cell cycle arrest and inhibition of JAK/STAT signalling pathway. J. BUON 24(2), 566-571 (2019).

3. Gan, L.-S., Zheng, Y.-L., Mo, J.-X., et al. Sesquiterpene lactones from the root tubers of Lindera aggregata. J. Nat. Prod. 72(8), 1497-1501 (2009).