A synthetic peptide CRF antagonist
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α-Helical CRF (9-41) (trifluoroacetate salt)

Item No. 35650

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • α-Helical Corticotropin-Releasing Factor (9-41)
Molecular Formula
C166H274N46O53S2 • XCF3COOH
Formula Weight
3826.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
DLTFHLLREMLEMAKAEQQEAALNRLLLEEA-NH2
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
OC(CC[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC=N1)NC([C@@H](NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@H](CC(O)=O)N[H])=O)CC(C)C)=O)=O)CC2=CC=CC=C2)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C166H274N46O53S2.C2HF3O2/c1-77(2)63-109(156(257)210-119(74-122(171)216)162(263)191-97(37-32-60-179-166(175)176)145(246)203-113(67-81(9)10)157(258)207-114(68-82(11)12)158(259)206-112(66-80(7)8)155(256)197-105(45-54-128(227)228)149(250)194-100(40-49-123(217)218)140(241)181-85(17)132(172)233)201-137(238)87(19)182-133(234)86(18)183-141(242)98(38-47-120(169)214)192-147(248)102(42-51-125(221)222)188-136(237)90(22)185-142(243)101(41-50-124(219)220)195-146(247)99(39-48-121(170)215)193-148(249)103(43-52-126(223)224)189-135(236)89(21)184-139(240)95(35-29-30-58-167)187-134(235)88(20)186-143(244)107(56-61-266-24)199-151(252)106(46-55-129(229)230)198-154(255)110(64-78(3)4)204-152(253)108(57-62-267-25)200-150(251)104(44-53-127(225)226)196-144(245)96(36-31-59-178-165(173)174)190-153(254)111(65-79(5)6)205-159(260)115(69-83(13)14)208-161(262)118(72-93-75-177-76-180-93)209-160(261)117(71-92-33-27-26-28-34-92)211-164(265)131(91(23)213)212-163(264)116(70-84(15)16)202-138(239)94(168)73-130(231)232;3-2(4,5)1(6)7/h26-28,33-34,75-91,94-119,131,213H,29-32,35-74,167-168H2,1-25H3,(H2,169,214)(H2,170,215)(H2,171,216)(H2,172,233)(H,177,180)(H,181,241)(H,182,234)(H,183,242)(H,184,240)(H,185,243)(H,186,244)(H,187,235)(H,188,237)(H,189,236)(H,190,254)(H,191,263)(H,192,248)(H,193,249)(H,194,250)(H,195,247)(H,196,245)(H,197,256)(H,198,255)(H,199,252)(H,200,251)(H,201,238)(H,202,239)(H,203,246)(H,204,253)(H,205,260)(H,206,259)(H,207,258)(H,208,262)(H,209,261)(H,210,257)(H,211,265)(H,212,264)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,227,228)(H,229,230)(H,231,232)(H4,173,174,178)(H4,175,176,179);(H,6,7)/t85-,86-,87-,88-,89-,90-,91+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,131-;/m0./s1
InChi Key
ABLXEDFBEVXOPX-XNDYOHLMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    α-Helical CRF (9-41) is a synthetic peptide antagonist of corticotropin-releasing factor (CRF).1 It inhibits CRF-induced adrenocorticotropic hormone (ACTH) release from isolated rat anterior pituitary cells when used at concentrations ranging from 0.5 to 5 µM. In vivo, α-helical CRF (9-41) (0.02-0.6 µmol/kg) inhibits CRF-induced ACTH release in non-anesthetized, intact rats. It also inhibits stress-induced ACTH release in rats when administered at a dose of 0.6 µmol/kg. α-Helical CRF (9-41) increases social interaction time in a rat model of nicotine-induced conditioned anxiety.2 It also reduces binge-like ethanol consumption in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rivier, J., Rivier, C., and Vale, W. Synthetic competitive antagonists of corticotropin-releasing factor: Effect on ACTH secretion in the rat. Science 224(4651), 899-891 (1984).

    2. Tucci, S., Cheeta, S., Seth, P., et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacol. (Berl) 167(3), 251-256 (2003).

    3. Lowery, E.G., Spanos, M., Navarro, M., et al. CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. Neuropsychopharmacology 35(6), 1241-1252 (2010).