An antimicrobial cationic peptide
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Magainin 1 (trifluoroacetate salt)

Item No. 35651

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-histidyl-L-seryl-L-alanylglycyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valylglycyl-L-α-glutamyl-L-isoleucyl-L-methionyl-L-lysyl-L-serine, trifluoroacetate salt
Synonyms
  • MG1
Molecular Formula
C112H177N29O28S • XCF3COOH
Formula Weight
2409.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
GIGKFLHSAGKFGKAFVGEIMKS-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]NCCCC[C@H](NC(CNC([C@](NC(CN[H])=O)([H])[C@H](CC)C)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@](C(N[C@@H](CCSC)C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(O)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)CC2=CC=CC=C2)=O)C)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)CC4=CC=CC=C4)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C112H177N29O28S.C2HF3O2/c1-12-65(7)93(139-86(144)54-117)110(166)122-59-89(147)128-75(39-25-29-46-115)100(156)135-81(51-70-33-19-15-20-34-70)105(161)133-79(49-63(3)4)104(160)136-83(53-72-55-118-62-123-72)106(162)137-84(60-142)108(164)124-67(9)95(151)119-56-87(145)127-74(38-24-28-45-114)99(155)134-80(50-69-31-17-14-18-32-69)97(153)120-57-88(146)126-73(37-23-27-44-113)98(154)125-68(10)96(152)132-82(52-71-35-21-16-22-36-71)107(163)140-92(64(5)6)109(165)121-58-90(148)129-77(41-42-91(149)150)103(159)141-94(66(8)13-2)111(167)131-78(43-48-170-11)102(158)130-76(40-26-30-47-116)101(157)138-85(61-143)112(168)169;3-2(4,5)1(6)7/h14-22,31-36,55,62-68,73-85,92-94,142-143H,12-13,23-30,37-54,56-61,113-117H2,1-11H3,(H,118,123)(H,119,151)(H,120,153)(H,121,165)(H,122,166)(H,124,164)(H,125,154)(H,126,146)(H,127,145)(H,128,147)(H,129,148)(H,130,158)(H,131,167)(H,132,152)(H,133,161)(H,134,155)(H,135,156)(H,136,160)(H,137,162)(H,138,157)(H,139,144)(H,140,163)(H,141,159)(H,149,150)(H,168,169);(H,6,7)/t65-,66-,67-,68-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,92-,93-,94-;/m0./s1
InChi Key
VCZQQHAUBCBLCV-WDGXWWQXSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    5 mg

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    Product Description

    Magainin 1 is a cationic peptide originally isolated from the skin of the African clawed frog (X. laevis) with roles in host defense and antimicrobial activity.1 It reduces germination percentage and mean tube elongation in kiwi fruit pollen (EC50s = 14 and 15.8 µM, respectively).2 Magainin 1 decreases viral replication in Vero cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 (EC50s = 36.59 and 33.2 µM, respectively) without affecting cell viability (CC50 = >100 µM).3 It induces apoptosis in HL-60 cells when used at concentrations of 10 and 50 µM and hemolysis in isolated human erythrocytes at 50 µM.4 Magainin 1 (10 and 50 µM) induces DNA fragmentation in HL-60 cells in a reporter assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nascimento, J.M., Franco, O.L., Oliveira, M.D., et al. Evaluation of magainin I interactions with lipid membranes: An optical and electrochemical study. Chem. Phys. Lipids 165(5), 537-544 (2012).

    2. Speranza, A.M., Taddei, A.R., and Ovidi, E. In vitro toxicity towards kiwifruit pollen of the antimicrobial peptides magainins 1 and 2. Plant Biol. (Stuttg.) 9(6), 800-806 (2007).

    3. Albiol Matanic, V.C., and Castilla, V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int. J. Antimicrob. Agents 23(4), 382-389 (2004).

    4. Cruz-Chamorro, L., Puertollano, M.A., Puertollano, E., et al. In vitro biological activities of magainin alone or in combination with nisin. Peptides 27(6), 1201-1209 (2006).