A dopamine uptake inhibitor
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GBR 12783 (hydrochloride)

Item No. 35662

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-piperazine, dihydrochloride
CAS Number
67469-75-4
Synonyms
  • Lu 2-098
  • MW-486
Molecular Formula
C28H32N2O • 2HCl
Formula Weight
485.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: Soluble
SMILES
N1(CCN(CC1)CC=CC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
InChi Code
InChI=1S/C28H32N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-17,28H,18-24H2;2*1H
InChi Key
HJDXBLLTRMCYNC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $193

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    25 mg

    $413

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    Product Description

    GBR 12783 is a dopamine uptake inhibitor (IC50 = 13 nM in rat striatal synaptosomes).1 It is selective for inhibition of dopamine uptake over norepinephrine or serotonin (5-HT) uptake (IC50s = 230 and 1,100 nM in rat hypothalamic and striatal synaptosomes, respectively). GBR 12783 (10 mg/kg, i.p.) improves learning and memory in the passive avoidance test in rats, an effect that can be blocked by the anticholinergic agent scopolamine.2 It increases locomotor activity, reduces pentobarbital-induced sleep duration, and decreases immobility time in the forced swim test, in mice.3 GBR 12783 (10 mg/kg) inhibits catalepsy induced by the antipsychotic haloperidol (Item No. 12014) in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonnet, J.J., and Costentin, J. GBR 12783, a potent and selective inhibitor of dopamine uptake: Biochemical studies in vivo and ex vivo. Eur. J. Pharmacol. 121(2), 199-209 (1986).

    2. Nail-Boucherie, K., Dourmap, N., Jaffard, R., et al. The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release. Brain Res. Cogn. Brain Res. 7(2), 203-205 (1998).

    3. Duterte-Boucher, D., Kamenka, J.M., and Costentin, J. Comparison of the effects of three indirect dopamine agonists, GK 13, GBR 12783 and dexamphetamine on behavioural tests involving central catecholaminergic transmissions. Psychopharmacology (Berl) 101(3), 344-353 (1990).