A dopamine uptake inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GBR 12783 (hydrochloride)

Item No. 35662

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-piperazine, dihydrochloride
CAS Number
67469-75-4
Synonyms
  • Lu 2-098
  • MW-486
Molecular Formula
C28H32N2O • 2HCl
Formula Weight
485.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: Soluble
SMILES
N1(CCN(CC1)CC=CC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
InChi Code
InChI=1S/C28H32N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-17,28H,18-24H2;2*1H
InChi Key
HJDXBLLTRMCYNC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $28

    Add

    5 mg

    $104

    Add

    10 mg

    $193

    Add

    25 mg

    $413

    Add
    Product Description

    GBR 12783 is a dopamine uptake inhibitor (IC50 = 13 nM in rat striatal synaptosomes).1 It is selective for inhibition of dopamine uptake over norepinephrine or serotonin (5-HT) uptake (IC50s = 230 and 1,100 nM in rat hypothalamic and striatal synaptosomes, respectively). GBR 12783 (10 mg/kg, i.p.) improves learning and memory in the passive avoidance test in rats, an effect that can be blocked by the anticholinergic agent scopolamine.2 It increases locomotor activity, reduces pentobarbital-induced sleep duration, and decreases immobility time in the forced swim test, in mice.3 GBR 12783 (10 mg/kg) inhibits catalepsy induced by the antipsychotic haloperidol (Item No. 12014) in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonnet, J.J., and Costentin, J. GBR 12783, a potent and selective inhibitor of dopamine uptake: Biochemical studies in vivo and ex vivo. Eur. J. Pharmacol. 121(2), 199-209 (1986).

    2. Nail-Boucherie, K., Dourmap, N., Jaffard, R., et al. The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release. Brain Res. Cogn. Brain Res. 7(2), 203-205 (1998).

    3. Duterte-Boucher, D., Kamenka, J.M., and Costentin, J. Comparison of the effects of three indirect dopamine agonists, GK 13, GBR 12783 and dexamphetamine on behavioural tests involving central catecholaminergic transmissions. Psychopharmacology (Berl) 101(3), 344-353 (1990).