A ligand for copper(I)-catalyzed azide/alkyne cycloaddition
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THPTA

Item No. 35670

Technical Information
Formal Name
4,4′,4′′-[nitrilotris(methylene)]tris-1H-1,2,3-triazole-1-propanol
CAS Number
760952-88-3
Molecular Formula
C18H30N10O3
Formula Weight
Purity
≥95%
A solid
DMSO: SolubleWater: Soluble
SMILES
OCCCN1C=C(N=N1)CN(CC(N=N2)=CN2CCCO)CC(N=N3)=CN3CCCO
InChi Code
InChI=1S/C18H30N10O3/c29-7-1-4-26-13-16(19-22-26)10-25(11-17-14-27(23-20-17)5-2-8-30)12-18-15-28(24-21-18)6-3-9-31/h13-15,29-31H,1-12H2
InChi Key
VAKXPQHQQNOUEZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    THPTA is a ligand for copper(I)-catalyzed azide/alkyne cycloaddition (CuAAC).1 It protects biomolecules from hydrolysis by copper(II) byproducts and against oxidation by various copper, oxygen, or ascorbate-derived radicals and peroxides.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Presolski, S.I., Hong, V.P., and Finn, M.G. Copper-catalyzed azide-alkyne click chemistry for bioconjugation. Curr. Protoc. Chem. Biol. 3(4), 153-162 (2011).