A derivative of 1,3-thiazolidin-4-one
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AKOS B018304

Item No. 35694

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(2-nitrophenyl)methylene]-2-thioxo-4-thiazolidinone
CAS Number
6308-22-1
Synonyms
  • NSC 43396
Molecular Formula
C10H6N2O3S2
Formula Weight
266.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: SolubleMethanol: Soluble
SMILES
O=[N](C1=C(C=CC=C1)C=C(C(N2)=O)SC2=S)=O
InChi Code
InChI=1S/C10H6N2O3S2/c13-9-8(17-10(16)11-9)5-6-3-1-2-4-7(6)12(14)15/h1-5H,(H,11,13,16)
InChi Key
CTTRUEBEEFZQBL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $417

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    10 mg

    $626

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    25 mg

    $1,043

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    Product Description

    AKOS B018304 is an arylalkylidene derivative of 1,3-thiazolidin-4-one.1 It inhibits the binding of ΔFosB to an oligonucleotide containing the activator protein-1 (AP-1) consensus site, Cdk5-AP-1, in a cell-free assay (IC50 = 10.1 µM).2 AKOS B018304 (12.5 µM) induces ΔFosB- and ΔFosB/JunD-mediated gene transcription in a reporter assay using Neuro2a cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jadav, S.S., Sinha, B.N., Hilgenfeld, R., et al. Thiazolidone derivatives as inhibitors of chikungunya virus. Eur. J. Med. Chem. 89, 172-178 (2015).

    2. Wang, Y., Cesena, T.I., Ohnishi, Y., et al. Small molecule screening identifies regulators of the transcription factor ΔFosB. ACS Chem Neurosci. 3(7), 546-556 (2012).